Susheel Kumar
Preclinical and clinical drug development is a protracted and difficult procedure. The Kingdom of Saudi Arabia (KSA) is showing an increased interest in promoting indigenous content, research, and innovation, including clinical trials (Phase I-IV). Saudi Arabia now has more than 650 registered clinical trials, and this number is anticipated to rise. Making sure that medications are used safely and effectively is a crucial component of drug research and clinical trials. Because it focuses on the effects of medications in humans, clinical pharmacology is essential for helping decision makers make well-informed choices during the drug development process. Clinical pharmacology includes areas of study include pharmacokinetics, pharmacodynamics, and pharmacogenomics. It is a developing field with numerous applications in all stages of Choosing the best dosages for Phase I, II, and III investigations, assessing bioequivalence and biosimilarity tests, and planning clinical studies are all part of drug development. Clinical pharmacology will be incorporated into research as well as regulatory bodies' requirements, which will enhance the drug development process and speed up the pipeline. Additionally, clinical pharmacology is used in hands-on patient care with the aim of individualised treatment. To optimise dosing for patients on an individual basis, techniques including therapeutic drug monitoring, pharmacogenomics, and model guided precision dosing are applied. Clinical pharmacology is a subject that is underutilised in KSA, so we think it's crucial to educate the scientific community and healthcare professionals about its potential and uses. In this review article, we give a summary of on the usage and applications of clinical pharmacology in medical treatment as well as drug development.
KeywordsLeonurus japonicas, Systems pharmacology, Menstrual disorders, Target prediction, Molecular docking
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